But Blount rushed for 88 yards in the fourth quarter alone, and Philadelphia ran out the clock after Henry's TD catch with to play.
Philip Rivers passed for 347 yards and two TDs for the Chargers, who have lost nine consecutive games dating to last season in San Diego.
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Carolina Panthers kicker Graham Gano, left, kicks the game-winning field goal as Michael Palardy (5) holds at the end of an NFL football game against the New England Patriots in Foxborough, Mass. It was the second home loss this season for the usually unbeatable Patriots at Gillette Stadium.
The winner served as redemption for Gano, who missed an extra point in the third quarter.
Cam Newton threw for three touchdowns and ran for another .
Jonathan Stewart rushed 14 times for 68 yards to pass De Angelo Williams and become the franchise's all-time leading rusher.
They used up of the extra session, which was shortened from 15 to 10 minutes this season. - Carson Wentz passed for 242 yards, Le Garrette Blount rushed for 136 and the Eagles extended their promising start to the season.
Rookie Jake Elliott kicked four field goals for the Eagles (3-1), who had thousands of roaring fans in the Chargers' temporary stadium while they hung on to win on the road for the second time in 10 tries.
Seattle's win came with a big blow in the final minutes when starting running back Chris Carson sustained a left leg injury. - Carson Palmer threw 19 yards to Larry Fitzgerald with 32 seconds left in overtime for the game's only touchdown.
The scoring had been limited to nine field goals on an ugly afternoon in the desert before Palmer directed a seven-play, 75-yard drive with to play.
They took a 23-22 lead on Rhett Ellison's 2-yard TD reception with remaining.